Did you check the stem for leaks? The valve in the end may be loose.
If it is a clean small nail/needle puncture in the tread that has not damaged the cord, a vulcanized patch from inside should be fine, even at speed.
Plugs are not great, and definitely make them a street only tire as they do damage the cord structure.
And yes, those little noise makers do their job. They got your attention didn't they?
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