In theory, as long as you can open/close valves when you want, number of cams is meaningless. In fact, more cams = more rotating mass and friction and possible miss timing between the cams even if only due to belt stretch.
2 cams more easily permits vvt and multi-valve intake/exhaust, but if you are not using those, then no real benefit.
Valve and spark plug position may be affected, which changes manifold flow, etc...
SOHC = KISS + cheaper.
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